neuropilin – Communicable Diseases Research

SARS-CoV-2 cell entry beyond the ACE2 receptor

Article

Published on 2022-11-012022-11-16
Journal: Molecular biology reports
[Category] COVID19(2023년), SARS, 변종,

In Silico and In Vitro Studies of Alchemilla viridiflora Rothm-Polyphenols’ Potential for Inhibition of SARS-CoV-2 Internalization

Alchemilla viridiflora Rothm-Polyphenols의 SARS-CoV-2 내재화 억제 가능성에 대한 실리코 및 체외 연구

Article

Published on 2022-08-142022-09-11
Journal: Molecules
[Category] SARS, 변종,

[키워드] ACE2 Alchemilla viridiflora Rothm. angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Antiviral agents binding binding energy binding interaction Compound computational studies Computational study Contact COVID-19 COVID-19 pandemic dose doses E484K effective Effectiveness exhibited flavonoid G476S glycoprotein Health higher affinity highest in silico in vitro inhibited inhibition internalization investigated K417N methanol molecular docking studies Molecular docking study Mutation N439K N501Y neuropilin Neuropilin-1 NRP1 outbreak plants polyphenols Potential Prevent quercetin receptor receptors resulting SARS-CoV-2 SARS-CoV-2 strain selected significantly spike glycoprotein spike glycoprotein. tested V483A virus virus infection Virus spike wild strain
[DOI] 10.3390/molecules27165174 PMC 바로가기 [Article Type] Article

An improved Fuzzy based GWO algorithm for predicting the potential host receptor of COVID-19 infection

Research article

Published on 2022-08-012022-10-05
Journal: Computers in biology and medicine
[Category] COVID19(2023년), SARS, 변종,

[키워드] ACE2 ACE2 protein acute respiratory syndrome ADAM17 Affect affected Algorithm analyzed ASGR1 Asialoglycoprotein Basigin Bone marrow Brain caused CD147 Cell CLEC4M Cluster Clustering Coronavirus-2 COVID-19 COVID-19 infection cytoplasm Differential evolution algorithm disease disintegrin domain drug effective Effectiveness eliminating entry of SARS-CoV-2 enzyme Evolution population dynamics exploratory expresse expression profile EXT1 EXT2 EXT3 Factor fusing Fuzzy clustering G protein-coupled receptor genetic diversity GLCE Glucuronic acid GPR78 Grey Grey wolf optimizer help Host host cell host cell membrane host receptor humans hybridizing I, II identify identifying IHC immunohistochemistry individual Infection inhibiting Interaction intestine kidney KREMEN1 Kringle liver lung mechanism membrane protein Membrane proteins Mutation NDST2 neuropilin NRP1 operator pathogenesis of COVID-19 pathogenesis of SARS-CoV-2 pathogenicity protease Protein PVR receptor replication of SARS-CoV-2 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein SARS-CoV-2 virus serine protease Seurat shown Single cell RNA sequencing data single-cell Spike protein spleen Spread therapeutic target TMPRSS2 toolkit transcriptionally transcriptomics transmembrane protein Transmission virus XYLT1 XYLT2
[DOI] 10.1016/j.compbiomed.2022.106050 [Article Type] Research article

Neuropilin (NRPs) Related Pathological Conditions and Their Modulators

뉴로필린(NRP) 관련 병리학적 상태 및 조절인자

Review

Published on 2022-07-292022-09-11
Journal: International Journal of Molecular Sciences
[Category] COVID19(2023년), SARS, 변종,

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1

ESCPE-1은 SARS-CoV-2 숙주 인자 Neuropilin-1의 역행 엔도솜 분류를 매개합니다

Article

Published on 2022-06-212022-09-11
Journal: Proceedings of the National Academy of Sciences of
[Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘,

Neuropilin-1-Mediated SARS-CoV-2 Infection in Bone Marrow-Derived Macrophages Inhibits Osteoclast Differentiation

골수 유래 대식세포의 뉴로필린-1 매개 SARS-CoV-2 감염은 파골세포 분화를 억제합니다

Article

Published on 2022-05-012022-09-11
Journal: Advanced Biology
[Category] COVID19(2023년), SARS, 변종,

[키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analysis angiotensin angiotensin-converting enzyme 2 B.1.351 bone Bone marrow bone marrow-derived macrophages calcium Clinical data Cluster Complication coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients damage dependent on differentiation Evidence expression host cell host cells Human skeleton humans identify impede in vivo Infection inhibit SARS-CoV-2 Interaction investigated knockdown macrophages marrow-derived macrophage metabolism mouse model Mouse models neuropilin Neuropilin-1 neutralization NRP1 organs osteoclast osteoclast differentiation Pathogenesis pathogenesis of SARS-CoV-2 patients phosphorus phosphorus metabolism provide receptor RNA sequencing SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection severe acute respiratory syndrome Coronavirus Severe acute respiratory syndrome coronavirus 2. significantly Single-cell RNA sequencing susceptible tissue tropism various tissue various tissues virus wild-type
[DOI] 10.1002/adbi.202200007 PMC 바로가기 [Article Type] Article

The roles of Eph receptors, neuropilin-1, P2X7, and CD147 in COVID-19-associated neurodegenerative diseases: inflammasome and JaK inhibitors as potential promising therapies

COVID-19 관련 신경퇴행성 질환에서 Eph 수용체, 뉴로필린-1, P2X7 및 CD147의 역할: 잠재적으로 유망한 치료법으로서 인플라마솜 및 JaK 억제제

Review

Published on 2022-02-022022-09-10
Journal: Cellular & Molecular Biology Letters
[Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 치료제,

[키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alzheimer’s disease angiotensin Angiotensin-converting enzyme antiviral drug antiviral drugs CD147 Central nervous system CNS conditions coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Critical cytokine Cytokines demonstrated Diseases effective entry receptor entry route Ephrin explain expression help host cells Inflammasome inhibitor Interaction Invasion involved Jak Ligand mechanisms neurodegenerative Neurodegenerative diseases neurodegenerative disorder neurodegenerative disorders neuropilin neuropilin 1 Neuropilin-1 Novel coronavirus novel coronavirus disease novel vaccines P2X7 pandemic Parkinson’s disease Pathogenesis pathological mechanism Protein provide receptor receptors respiratory Safe SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus Spread therapeutic strategy therapy Vaccine Vaccines with COVID-19
[DOI] 10.1186/s11658-022-00311-1 PMC 바로가기 [Article Type] Review

A New Butyrate Releaser Exerts a Protective Action against SARS-CoV-2 Infection in Human Intestine

새로운 부티레이트 방출제는 인간의 장에서 SARS-CoV-2 감염에 대한 보호 조치를 취합니다

Article

Published on 2022-01-272022-09-10
Journal: Molecules
[Category] SARS, 유전자 메커니즘, 치료제,

[키워드] ACE2 Action Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 administration alteration angiotensin angiotensin-converting enzyme-2 Antiviral antiviral response butyramide Butyrate carbamoyl Characteristics coronavirus COVID-19 Cytokines Defense defense mechanisms Diseases enterocytes enzyme expression FBA functional Gut gut microbiome Host Human IL-15 infected cells Infection Infectious diseases intestinal models investigated involved limit MCP-1 mechanism metabolite Microbiome modulate monocyte monocyte chemoattractant protein-1 neuropilin Neuropilin-1 New NF-kB NRP1 nuclear oral administration Pathways Patient presenting pro-inflammatory cytokine pro-inflammatory cytokines protease Protective receptor reduce reduced reducing regulate Releaser reported respiratory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-infected cells Serine serine 2 several gene several genes severe acute respiratory syndrome Coronavirus small intestinal biopsy small intestine TMPRSS2 TNF-α transmembrane transmembrane protease serine 2 up-regulation viral infection
[DOI] 10.3390/molecules27030862 PMC 바로가기 [Article Type] Article

Hydroxychloroquine treatment on SARS-CoV-2 receptor ACE2, TMPRSS2 and NRP1 expression in human primary pterygium and conjunctival cells

인간의 일차 익상편 및 결막 세포에서 SARS-CoV-2 수용체 ACE2, TMPRSS2 및 NRP1 발현에 대한 히드록시클로로퀸 치료

Multicenter Study

Published on 2022-01-012022-09-11
Journal: Experimental eye research
[Category] SARS, 바이오마커,

[키워드] ACE2 ACE2 protein acute respiratory syndrome acute respiratory syndrome coronavirus angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 applied binding Cell cell viability cells Combination concentration of hydroxychloroquine Conjunctiva conjunctival coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 treatment decrease elevated enzyme epithelial evaluate expression fibroblasts host cell host cell receptor Hydroxychloroquine hydroxychloroquine treatment increase in Infection influences neuropilin Neuropilin-1 NRP1 oxidative stress pandemic pathogen Protein protein expression Pterygium reduced reduction respiratory ROS production SARS-CoV-2 SARS-CoV-2 receptor Serine severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Side effect significantly SOD2 Spike protein tissue TMPRSS2 TMPRSS2 expression TMPRSS2 inhibitor TMPRSS2 protein TMPRSS2. transmembrane serine protease Treatment Treatment strategies type II transmembrane serine protease viability
[DOI] 10.1016/j.exer.2021.108864 PMC 바로가기 [Article Type] Multicenter Study

Effects of Weight Loss on Adipose and Muscular Neuropilin 1 mRNA Expression in Obesity: Potential Implication in SARS-CoV-2 Infections?

비만에서 지방 및 근육성 뉴로필린 1 mRNA 발현에 대한 체중 감소 효과: SARS-CoV-2 감염에 대한 잠재적 영향?

Randomized Controlled Trial

Published on 2022-01-012022-09-11
Journal: Obesity facts
[Category] SARS, 비임상, 임상,

[키워드] ACE-2 adipose Adipose tissue age animal body mass body mass index body weight breath changes Clamp control group driven by Effect estimate expressed fatty Fatty acid female Follow-up followed by free fatty acid improvement indicate insulin Insulin sensitivity insulin sensitivity index Intervention involved lipid transport liver Loss mRNA mRNA expression neuropilin neuropilin 1 obesity Phenotyping Potential Randomized receptor reduction SARS-CoV-2 Skeletal muscle storage Stratified randomization subject subsequent susceptibility tendency tissue was measured was performed weight weight loss Weight loss. Weight reduction whole body
[DOI] 10.1159/000520419 PMC 바로가기 [Article Type] Randomized Controlled Trial